Tobramycin

Ophthalmic tobramycin is used to treat eye infections. Tobramycin is in a class of medications called antibiotics. It works by killing bacteria that cause infections.

Ophthalmic tobramycin may be used alone or with other medicines for eye infections. Either the drops or the ointment form of this medicine may be used alone during the day. In addition, both forms may be used together, with the drops being used during the day and the ointment at night.

Dose:

Tobrex Ophthalmic Solution

  • In mild to moderate disease, instill one or two drops into the affected eye(s) every four hours.
  • In severe infections, instill two drops into the eye(s) hourly until improvement, following which treatment should be reduced prior to discontinuation.

Tobrex Ophthalmic Ointment

  • In mild to moderate disease, instill a half inch ribbon into the conjunctival sac of the affected eye(s) two to three times per day.
  • For severe infections, instill a half-inch ribbon into the conjunctival sac of the affected eye(s) every three to four hours until improvement is detected. Following improvement, treatment should be reduced prior to discontinuation.

How Supplied:  5ml solution or 3.5g metal ointment tube, which dispenses a ribbon of ointment.

Pregnancy: (Category B)  There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed.

Children: Safety and effectiveness in pediatric patients below the age of 2 months has not been established.

Common Side Effects:   Serious side effects are not expected with this medication.

  • eyes tearing
  • itching, stinging, or burning of the eye
  • swelling of the eye
  • temporary blurred vision (from the ointment)

Adverse Reactions:  The most frequent adverse reactions to Tobrex® Ophthalmic Solution are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than three of 100 patients treated with Tobrex®. Similar reactions may occur with the topical use of other aminoglycoside antibiotics. Other adverse reactions have not been reported from Tobrex® (tobramycin ophthalmic solution) 0.3% therapy.

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