Pred Forte

pred_forte

Because many eye problems, as well as many eye surgeries, are associated with inflammation, Pred Forte is an important part of our drug formulary in eye care. PRED FORTE® is indicated for the treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

How does it work?

Pred forte eye drops contain the active ingredient prednisolone, which is a type of medicine called a corticosteroid (or steroid). Corticosteroids are used for reducing inflammation. (They should not be confused with another type of steroid, called anabolic steroids, that have gained notoriety due to their abuse by some athletes and body builders.)

Inflammation occurs as a result of allergy or irritation and is caused by the release of substances that are important in the immune system. These substances cause blood vessels to widen, resulting in the affected area becoming red, swollen, itchy and painful.

Corticosteroids are hormones produced naturally by the adrenal glands that have many important functions, including control of inflammatory responses. They work by acting within cells to decrease the release of inflammatory substances, thereby reducing swelling, redness and irritation.

Prednisolone is a synthetic corticosteroid that can be adminstered into the eyes to decrease local inflammation, for example caused by chemicals, heat, radiation, allergy, or foreign objects in the eye. It is sometimes used after eye surgery.

How we use this drug: Pred Forte is the standard of care when it comes to topical steroids.  We use this drug for all significant inflammatory problems in the eye.  Profound inflammation can actually be destructive to the delicate tissues in the eye.

It can be used in conjunction with other drugs to solve complex ocular disease issues or in post operative care.

Special Note:  Pred Forte has become available as a generic (Prednisolone acetate by Falcon Pharmaceutical).   Prednisolone acetate (the generic) is not nearly as effective as the branded drug.  For this reason, it is one of the few drugs that we write “dispense as written” (abbreviated “DAW”) on your prescription for Pred Forte.

Supplied:

  • 5 mL in 10 mL bottle
  • 10 mL in 15 mL bottle
  • 15 mL in 15 mL bottle

Dose: Shake well before using. The dose of Pred Forte varies greatly with the disease being treated, For mild inflammation, instill one to two drops into the conjunctival sac two to four times daily.  Profound inflammatory conditions may require initial dosing of one to two drops every hour.

During the initial 24 to 48 hours, the dosing frequency may be increased if necessary. Care should be taken not to discontinue therapy prematurely. If signs and symptoms fail to improve after 2 days, the patient should be re-evaluated

Children: Safety and effectiveness in pediatric patients have not been established.  In general, we don’t use Pred Forte in children under 12 years of age.

Pregnancy: There are no adequate well-controlled studies in pregnant women.  Prednisolone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. (Category C)

Special Note: As a rule, significant ocular inflammations require the original branded product – Pred Forte.  It continues to be the better option because of the bioavailability of the drug—the generic just does not work the same way on the eye. It just does not penetrate the cornea and get to the site of action where we really need it to go.

 Not to be used in:

  • Severe untreated bacterial eye infections.
  • Viral infections of the eye, eg herpes simplex.
  • Fungal infections of the eye.
  • Tuberculosis of the eye.
  • Glaucoma
  • These drops should not be used to treat a red eye that has not been diagnosed by a doctor, as inappropriate use can cause blindness.

Side effects:

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

  • Temporary blurred vision after putting the drops in the eye(s).
  • Irritation, itching, stinging or burning sensation in the eye(s).
  • Thinning of the cornea or sclera (the tissues which cover the outer surface of the eye).
  • Increase in the pressure inside the eye (glaucoma) which may lead to problems with your sight. If you experience a feeling of pressure or pain in your eye(s) while using these eye drops you should tell your doctor straight away.  If this product is used for 10 days or longer, intraocular pressure should be routinely monitored.
  • If used in the eye frequently or for long periods of time, corticosteroids such as this one can cause partial loss of vision due to cloudiness in the lens of the eye (cataracts).
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