In patients with an allergy to penicillin a safe approach would be to use a different class of antibiotic altogether. In true penicillin-allergic patients, we tend to favor levofloxacin (Levaquin and its generic).
Levaquin (levofloxacin) is in a group of antibiotics called fluoroquinolones (flor-o-KWIN-o-lones). Levaquin fights bacteria in the body. LEVAQUIN® Tablets/Injection and Oral Solution are indicated for the treatment of adults ( ≥ 18 years of age) with mild, moderate, and severe infections caused by susceptible isolates.
Supplied: Tablets: 250 mg, 500 mg, or 750 mg Solution: Oral Solution, 25 mg/mL
Dose: 500mg daily for one week. Take Levaquin with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking Levaquin. You may take Levaquin tablets with or without food, although, it is recommended that Levaquin® Oral Solution be taken 1 hour before or 2 hours after eating.
Warnings: Like all antibiotics, Levaquin works only against bacteria. It will not cure an infection caused by a virus, such as the common cold or flu.
In rare cases, antibiotics can cause a serious allergic reaction. Stop taking Levaquin and call your doctor immediately if you develop any of the following warning signs: skin rash, tingling, hives, swelling of the face or throat, difficulty breathing or swallowing, rapid heartbeat, or yellowing of the skin or eyes.
A rare but serious side effect of Levaquin is tendon rupture or swelling of the tendon. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. Stop taking Levaquin and call your doctor immediately if you notice any tendon pain, swelling, or inflammation.
Fluoroquinolones, including Levaquin®, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid Levaquin® in patients with a known history of myasthenia gravis.