Combigan contains brimonidine (Alphagan P) and timolol.

Brimonidine is an alpha-agonist that reduces the amount of fluid in the eye, which decreases pressure inside the eye.  Timolol is a beta-blocker that also reduces pressure inside the eye.

Combigan is used to treat glaucoma or ocular hypertension (high pressure inside the eye).  Combigan may also be used for other purposes not listed in this guide.

Supplied:  5 mL in 10 mL bottle, 10 mL in 10 mL bottle

Dose: The recommended dose is one drop of COMBIGAN® in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.

Children: Combigan® is contraindicated in neonates and infants (under the age of 2 years).

Pregnancy: (Category C) Combigan® should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.

Side Effects: Get emergency medical help if you have any of these signs of an allergic reaction to Combigan: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

  • severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • pounding heartbeats or fluttering in your chest;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
  • feeling like you might pass out;
  • numbness, tingling, or cold feeling in your hands or feet;
  • muscle weakness; or
  • confusion, hallucinations, unusual thoughts or behavior.

Precautions:  You should not use Combigan if you are allergic to brimonidine (Alphagan) or timolol (Timoptic, Cosopt), or if you have certain conditions. Be sure your doctor knows if you have:

  • asthma, or severe chronic obstructive pulmonary disease (COPD)
  • heart disease or heart failure
  • slow heartbeats

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